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Edited by Patricia Kahn
This completely revamped and international edition provides an overview of the key scientific, policy, social, ethical and economic challenges, and of the diverse experience gained around the world over the past two decades. The easy-to-read, lively essays are written by people involved in this work as community educators and advocates, trial staff and volunteers, scientists and researchers, and policy-makers and journalists. AVAC hopes this new handbook serves well as a resource and reference guide - and this is motivates people to take action!
Click here to read a review of the handbook published in the South African Medical Research Council's AIDS Bulletin - December 2005
To obtain printed copies of the AIDS Vaccine Handbook, please click here or call the National Prevention Information Network (NPIN) at 1 800 458-5231 and ask for inventory item E198.
For orders outside the US, send us an email at handbook@avac.org.
To view the original edition published in 1999, click here.
To obtain a printed copy send an email to handbook@avac.org.
AIDS Vaccine Handbook: Global Perspectives (electronic version)
Click on the bold section titles to view entire sections of the handbook (large files), or click on titles to view each section (smaller files).
Download the Entire Handbook (11.6 MB)
Introduction & Forward
Contents
An Epidemic That Rages On
Mitchell Warren
Section 1. Overview
Why We Need Vaccine Activism, Still
Bill Snow
Where Are We In the Search for an AIDS Vaccine?
Patricia Kahn
HIV in Pictures
Patricia Kahn and Roberto Fernandez-Larsson
Section 2. AIDS Vaccine Science
Vaccine Basics
Bill Snow
The Immune System in Pictures
Text by Patricia Kahn / Illustrations by Lew Long
Vaccine Development: From Concept to Licensed Product
Huntly Collins
AIDS Vaccine Approaches in Development
Patricia Kahn
Vaccines that Trigger Cellular Immunity: What Can We Hope For?
Richard Jefferys
Partially Effective Vaccines
Emily Bass
Do Clades Matter for AIDS Vaccines?
Patricia Kahn
Testing AIDS Vaccines in People
Emily Bass and Patricia Kahn
Testing for Immune Responses to HIV:
The Science in Pictures
Patricia Kahn and Michael Hoelscher
Section 3. Clinical Trials
Being a Trial Volunteer: What Happens?
Scott Carroll and Patricia Kahn
Is It Safe?
Pat Fast
Research Ethics: Recipe for Success
Bill Snow
Informed Consent in HIV Vaccine Trials
Graham Lindegger / South Africa
Community Advisory Boards
Steve Wakefield
Community Education: Working Together
Mônica Barbosa de Souza / Brazil
Ensuring Community Participation and Readiness:
A Conversation with Janet Fröhlich
Janet Fröhlich with Patricia Kahn / South Africa
Vaccine Trials: Leaving Communities Better Off
Adapted from the AVAC REPORT 20041
HIV Vaccine Trials in Uganda: Personal Experience as an Investigator
Pontiano Kaleebu / Uganda
Facing Failure on the Way Towards Success:
Lessons Learned from the VaxGen Trial
Richard Jefferys
Testing Vaccines in Injecting Drug Users:
VaxGen's Efficacy Trial in Thailand
Introduction by Patricia Kahn
Section 4. Communities and Cohorts
Women, AIDS and the Search for a Vaccine
Sushma Kapoor / India
Challenges Recruiting Women Into Trials
Sabina Wakasiaka / Kenya
AIDS Research with Sex Workers: Lessons Learned
Emily Bass
Thai Drug Users Network, AIDS and Human Rights:
A Conversation with Karyn Kaplan
Karyn Kaplan with Patrica Kahn / Thailand
Adolescents and AIDS Vaccine Research in the United States
Audrey Smith Rogers / USA
Adolescents in HIV Vaccine Trials: Perspective from Botswana
Tonya L. Villafana, Nthabiseng Phaladze, Christine Stegling,
Rupert HambIra, Peninah Thumbi, Joseph Makhema / Botswana
Testing STD Vaccines in Young People: How it's Done
Huntly Collins
A Queer Eye on AIDS Vaccine Development
Edd Lee
AIDS Prevention and African Militaries:
A Conversation with Colonel Deborah Birx
Colonel Deborah Birx with Patricia Kahn
Section 5. Global Advocacy
Community Matters: (Re)-defining Our Advocacy
Shaun Mellors / South Africa
From Trial Volunteer to Vaccine Advocate
Paul Wetaka / Uganda
Speed and Equity: Why Political Leadership is Important
Chris Collins
Ensuring Rapid Global Access to AIDS Vaccines
David Gold
Just 2 Drops: Polio Eradication in Pictures
Text by Patricia Kahn / Photos from the World Health Organization Archives
Section 6. Voices
Working with Communities: 1991
Bill Snow
Coming of Age Amid Grief, Death and AIDS
Garance Franke-Ruta
Terms of Engagement: How Communities Helped Shape Brazil's AIDS Vaccine Agenda
Alex Menezes / Brazil
AIDS, South Africa, Stigma, Vaccines: A Conversation with Justice Edwin Cameron
Justice Edwin Cameron with Patricia Kahn / South Africa
Going First: A Conversation With Anthony Morris
Anthony Morris with Patricia Kahn / USA
Going First: A Conversation With Mdu Nkosi
Mdu Nkosi with Liz Clarke / South Africa
Section 7. Appendix
The Authors
Trial Sites Around the World
Ongoing Clinical Trials
Organizations Involved With AIDS Vaccines / About AVAC
Glossary
Index
This website Copyright 2006 AIDS Vaccine Advocacy Coalition
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