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2008 AVAC Report The Search Must Continue

The 2008 AVAC Report, The Search Must Continue,     provides a comprehensive review of recent developments in AIDS vaccine research. It explores the issues that have been raised in the wake of the failure of Merck's vaccine candidate and provides context for the events and major changes of the last year in HIV prevention research.

In the report, AVAC argues that continuing to move forward with AIDS vaccine research and testing is imperative and lays out recommendations for the AIDS vaccine and HIV prevention field. It also looks at the comparative advantages of major players, including the U.S. National Institutes of Health and the International AIDS Vaccine Initiative, and analyzes the current environment for decision-making about future clinical trials.

The Search Must Continue - click to download the full PDF

The Story that Must be Told: A letter from the Executive Director

AVAC's Top 10 Recommendations for 2008 and Beyond
AVAC Report 2008 At a Glance

Status Report - An Update on Last Year's Recommendations

Chapter 1: The Whole Wide World: Global priorities around HIV prevention research

Figure 1: HIV Prevention Research : A Comprehensive Timeline of Anticipated Results from Efficacy Trials
Table 1: Ongoing and Planned PrEP Trials (April 2008)
Figure 2: Ongoing Trials of New Prevention Options Worldwide (April 2008)

Chapter 2: What 's ( Y )our Position? Where we stand in the post-STEP era

Figure 3: The Era of Flat Funding: NIH and NIAID AIDS Research Funding FY 1989-2009
Figure 4: Losing Power: The Impact of Inflation on the Flat NIH Budget
Table 2: Ongoing Trials of Preventive HIV/AIDs Vaccine Worldwide (April 2008)
Figure 5: Why An AIDS Vaccine is Possible

Chapter 3: What We Know for Sure: Lessons to be learned from the STEP study
Figure 6: Starting the "Post-STEP" Era: A Timeline
Figure 7: All in This Together: Layers of the Aids Vaccine Community
Figure 8: Projected HIV Prevalence By Age: US and African-American MSM
Figure 9: HIV Prevalence by Age Among US and African-America MSM: Current Estimates
Figure 10: Data on Rates of Report Risk Behavior Among Male Volunteers in the STEP Trial
Table 3: Proportion of STI Prevention Expenditures Targeted at MSM in Asia

Chapter 4: Moving Forward, Looking Back: Studying the IAVI model
Figure 11: Annual Public and Philanthropic Investments in Preventive HIV Vaccine R&D from 2000 to 2006
Figure 12: Financing the Search
Figure 13: Global Distribution of Vaccine Trial Sites

Science Snapshot: Quick Takes on Next Steps in the Search for an AIDS Vaccine

AVAC: Global Advocacy for HIV Prevention
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