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Anticipating and Understanding the Results of the Phase III AIDS Vaccine Trial in Thailand

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Bloomberg News features P5 and its efforts to improve on RV144 results - Bloomberg News, June 2012
AIDS Vaccine Science for Busy Advocates: Building on RV144 - AVAC, May 2012
Update: A big week for combination prevention - AVAC, September 2011
AVAC's Statement on HIV Vaccine Awareness Day 2011 - AVAC, May 2011
The Search for Antibody Correlates of Protection for HIV-1 Acquisition in RV144: An update - U.S. Military HIV Research Program presentation at CROI 2011

On Thursday, September 24, 2009 initial results were released from an AIDS vaccine phase III trial in Thailand, which showed, for the first time, that the risk of HIV infection can be reduced by a vaccine (press coverage and AVAC statement below).

On October 20, 2009 at the annual AIDS Vaccine Conference, the investigators for the Thai prime-boost AIDS vaccine trial presented the results of additional data analyses. The presentation coincided with the publication of the results in the New England Journal of Medicine (links below). A webcast of the presentations made in Paris is available at the AIDS Vaccine 2009 webpage.

Key Resources
The Thai Way Forward - AVAC, May 2010. A Thai translation of this excerpt will be available soon.
Phase III HIV Vaccine Trials page - U.S. Military HIV Research Program, updated regularly.
Understanding the results of RV 144, the Thai prime-boost AIDS vaccine trial - by Deirdre Grant and Emily Bass, POZ, March 2010
Understanding the Thai Prime-Boost Vaccine Trial Results Update FAQ - AVAC, October 2009
RV 144 Phase III Trial-Thailand Fact Sheet - U.S. Military HIV Research Program, October 2009
Anticipating the Results of the Phase III AIDS Vaccine Trial in Thailand (English and Thai) - AVAC, September 2009

October 20, 2009
The peer-reviewed Thai trial results have been published and were accompanied by an editorial response by Raphael Dolin:
ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand - New England Journal of Medicine, October 20, 2009
HIV Vaccine Trial Results — An Opening for Further Research - New England Journal of Medicine, October 20, 2009

Media coverage, understanding the initial results
Have Faith in an AIDS Vaccine - New York Times, October 18, 2009
An AIDS Vaccine is Now More than a Dream - Huffington Post, October 5, 2009
San Francisco AIDS Foundation biweekly update on HIV/AIDS, podcast - SFAF, October 1, 2009

September 24, 2009
Initial results were released, which showed, for the first time, that it is possible to reduce the risk of HIV infection with a vaccine.
Trial FAQs prepared by the trial sponsor.

Press releases and statements:
AVAC's press release
Press release from the trial sponsor
Global HIV Vaccine Enterprise Hails Significant Results from HIV Vaccine Study in Thailand - The Enterprise
IAVI Statement on Results of Phase III ALVAC-AIDSVAX Trial in Thailand

Civil society calls:
AVAC held a civil society call to discuss the trial and the initial results on Thursday, September 24. This call provided an opportunity for advocates to discuss the results with the researchers and to ask questions about the results and related issues the data may raise.
Click here to listen to a recording of the call (audio/mpeg).

Select media coverage of the initial result:
Cause for Caution on the Results of the ALVAC/AIDSVAX HIV Vaccine Efficacy Trial: More Marginal than "Modest" - TAG,  September 25, 2009
An unpopular vaccine study produces surprising result - aidsmap, September 24, 2009
First positive results from an HIV vaccine - IRIN/PlusNews, September 24, 2009
For First Time, AIDS Vaccine Shows Some Success in Trials - New York Times, September 24, 2009
HIV Vaccine Shows Promise for First Time, Study Shows  - Bloomberg News, September 24, 2009
Massive AIDS Vaccine Study a "Modest" Success - Science Insider, September 24, 2009
Vaccine trial "is the beginning" of a new path of research, says US health chief  - aidsmap, September 24, 2009
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