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AVAC publications aim to translate the complex issues of biomedical HIV prevention research for a range of audiences. We have materials that explain current scientific issues in simple language, and other documents that explore the issues and expertise of communities that are affected by and asked to participate in clinical trials.

AVAC Report

For 16 years, AVAC has published an annual review of biomedical prevention research. Over this period, the focus of the AVAC Report has expanded from AIDS vaccine research alone to the full spectrum of options, including pre-exposure prophylaxis, HSV-2 treatment, microbicides and male circumcision. This comprehensive document reviews progress, makes recommendations and analyses emerging issues.

Visit the AVAC Reports page for summaries of and links to this year's and past AVAC reports.


Px Wire is AVAC's quarterly update on biomedical HIV prevention research. Each issue includes a comprehensive timeline of ongoing efficacy trials around the world and a map showing where in the world these trials are happening. Each issue also includes updates on news, emerging issues and upcoming events.

Click here for more information and to download the latest issue.

Anticipating and Understanding Results

The Anticipating and Understanding Results
series provides timely analysis of emerging or recently-announced trial results. Past publications in the series have explored the trials of male circumcision for HIV prevention, pre-exposure prophylaxis and the Thai prime-boost vaccine efficacy trial.

PrEP Primer

This primer provides an introduction to pre-exposure prophylaxis (PrEP) research for HIV prevention, including basic information on PrEP strategies being studied, the scientific rationale for PrEP, the state of the research, who is involved in PrEP, what additional research may be needed, and how to prepare for upcoming trial results.

Making Medical Male Circumcision Work for Women

This report is one component of ongoing civil society work in countries to elevate women’s concerns and to ensure that the rollout of medical male circumcision as an HIV prevention strategy is beneficial and safe for women. Over the next year, Women's HIV Prevention Tracking Project (WHiPT) teams will execute advocacy plans based on the findings reported here.

Click here for individual country reports, a two-page summary, and more related materials.

Microbicides: Ways Forward

Microbicides: Ways Forward is the final in a series of strategy documents put out by the Alliance for Microbicide Development (AMD). In 2009, the Alliance surveyed a number of microbicides experts and key stakeholders in the field in an effort to identify area of progress, obstacles that remain and priorities for the field. These conversations and insights inform much of the new report, which concludes with nine key recommendations for moving the microbicide field forward. The Alliance officially closed at the end of 2009 and this new report is one of many key AMD resources that we will be integrating into our continually expanding education, outreach, advocacy and policy work.

AIDS Vaccine Handbook

Published in 2005 the AIDS Vaccine Handbook (second edition) provides an overview of the key scientific, policy, social, ethical and economic challenges related to AIDS vaccine development. The easy-to-read, lively essays are written by community educators and advocates, trial staff, volunteers, scientists, policy-makers, and journalists.

Visit the AIDS Vaccine Handbook page to view an electronic version of the handbook and to get ordering information.

Resource Tracking
The HIV Vaccines and Microbicides Resource Tracking Working Group was established in 2004 to generate and disseminate high-quality, detailed and comparable data on global  investments in preventive HIV vaccine and microbicide research and development (R&D), and policy and advocacy activities.  In 2006, the Working Group expanded its tracking efforts to include other experimental HIV prevention options, such as adult male circumcision, HSV-2 suppression and pre-exposure prophylaxis (PrEP). Since 2004, the Working Group has published an annual report on HIV prevention research and development. Each report tracks investments from the previous year as well as the trends back to 2000. By identifying and tracking the resources invested in HIV prevention research and development these reports are intended to serve as a key to understanding and evaluating the global response to the HIV/AIDS pandemic.

The Good Participatory Practice (GPP) Guidelines for Biomedical HIV Prevention Trials, 2nd Edition (2011)

The good participatory practice (GPP) guidelines are intended to provide trial funders, sponsors, and implementers with systematic guidance on how to effectively engage with all stakeholders in the design and conduct of biomedical HIV prevention trials.

For more information visit www.avac.org/gpp.

Communications Handbook for Clinical Trials

This handbook provides practical guidance to clinical trial staff and research partners on how to anticipate and respond to the special communications challenges posed by the conduct of clinical research. Organized to correspond to the chronological steps involved in conducting research, this guide focuses on the various communications skills that are needed throughout the course of a trial.

For more information and to download a PDF of the book or its individual chapters, click here.
Finding Your Way

Developed by AVAC in partnership with the International Council of AIDS Service Organizations (ICASO) in 2005, this guide provides an introduction to the ethical principles raised in preventive  HIV vaccine research and development, and examples of some of the actions taken to honor those principles.


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