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The term “microbicide” refers to substances being studied that could be used in the vagina and/or rectum to reduce the risk of HIV infection via sexual exposure. There are no licensed microbicides available today. Vaginal and rectal microbicides could be additional prevention tools for women and men at risk of HIV around the world. Today, daily oral PrEP is the only prevention tool that women can use to reduce risk of HIV that does not require partner negotiation at or around the time of sex. Access to this strategy is limited and expanding slowly. But more options are needed. Simple, easy-to-use vaginal microbicides would fill an important HIV prevention need.

While no microbicide is commercially available, clinical trials could lead to licensing of the first products within this decade. To ensure that people can benefit quickly, the foundation for rollout must be laid now by exploring the feasibility, acceptability and impact of introducing new tools like oral PrEP and developing combination prevention platforms where new products can be easily introduced.

Results from two Phase III multi-country trials (ASPIRE and Ring) studying the 4-week slow-release dapivirine vaginal ring were released at the Conference on Retroviruses and Opportunistic Infection. Click here for press releases, background information and other useful resources about the Ring and ASPIRE studies.

What We're Reading

The International Partnership for Microbicides announces its application to European regulators to market the dapivirine vaginal ring for HIV prevention. If approved, the ring would be the world’s second biomedical HIV prevention option ever to reach the marketplace. The first was the daily oral pill known as Truvada, taken as pre-exposure prophylaxis (PrEP), which was approved in the US in 2012. The vaginal ring would be the first longer-acting HIV prevention product available to HIV-negative women.

July 13, 2017
The International Partnership for Microbicides

Expanding women’s options for HIV prevention, the International Partnerships for Microbicides (IPM) has been working to develop the dapivirine vaginal ring. As Durban hosted the 8th annual SA AIDS conference, South Africa’s Daily News reported on 9 things you need to know about this long-acting, discreet HIV prevention method.

June 15, 2017
General, Microbicides
Daily News

POZ reports on a study presented at CROI 2017, which showed that dapivirine vaginal ring does not affect the effectiveness of hormonal contraception

February 15, 2017
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