HIV/AIDS and Cure Basics - Module 4

Latency Reversing Agents

Latency reversing agents are small pharmacological molecules that could help uncover where HIV is hiding in the cells of HIV-positive individuals whose viral load has been suppressed below the level of treatment by effective HAART. Researchers are investigating these molecules hoping they may be part of a combination approach to eradicating HIV. This module will give an overview of the research currently being pursued using these small molecules and place this research in the larger framework of the HIV cure research agenda.

• PowerPoint 
• Find your Match (coming soon) 
• Assessment  
• Latency Reversing Agents Webinar: Stream // Download

For additional resources check out:

• Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation
• Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
• Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy