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Long-acting injectable PrEP is an experimental strategy based on the drug cabotegravir, an antiviral medication.
Two studies, HPTN 083 and HPTN 084, have shown high levels of protection using cabotegravir as a long acting injectable (CAB-LA). HPTN 083 gathered data among men who have sex with men, transgender women. HPTN 084 investigated the same product among cisgender women.
Scroll down for resources on CAB-LA research and advocacy.
Understanding the Research Results
- An Advocates’ Primer on Long-Acting Injectable Cabotegravir for PrEP: Understanding the Initial Results of HPTN 083, AVAC, April 2021
- Landmark Trial in East and Southern Africa Finds Injectable PrEP Safe and Effective for Cisgender Women, AVAC, November 2020
- Resource page on HPTN 084 trial design and results, HPTN, November 2020
- HPTN 084 FAQ, HPTN, November 2020
- Resource page on HPTN 083 trial design and results, HPTN, July 2020
- HPTN 084 Primary Study Results Webinar, HPTN, November 2020
- HPTN 083 FINAL RESULTS: Pre-exposure Prophylaxis containing long-acting injectable cabotegravir is safe and highly effective for cisgender men and transgender women who have sex with men, presentation at AIDS 2020, July 8, 2020
Putting the Research in Context
- A Conversation About Long-Acting PrEP for Cisgender Women, a conversation between Sinead Delany-Moretlwe, HPTN 084 Study Chair and Awelani Neluonde, CAB Member, AVAC’s Research Literacy Networking Zone at AIDS 2020, July 2020
- A Conversation About Long-Acting PrEP for MSM & Transgender Women, a conversation between Raphael Landovitz, HPTN 083 Study Chair and Jessica Salzwedel of AVAC, AVAC’s Research Literacy Networking Zone at AIDS 2020, July 2020
- Biomedical Prevention Implementation Collaborative (BioPIC) — Funded by the Bill & Melinda Gates Foundation as part of the AVAC and CHAI HIV Prevention Market Manager project, BioPIC is designed to close the gap between research and rollout for CAB-LA and future products
- Testing Long-Acting PrEP, Easier Said Than Done, Px Pulse podcast, October 2017 — Researcher and statistician Deborah Donnell describes the two different design approaches to the trials testing long-acting cabotegravir
- Px Wire: A Quarterly Update on HIV Prevention Research, April–June 2017, AVAC — This issue of Px Wire offers a guide to new types of trial designs, a summary of long-acting PrEP trials, a lexicon of key terms for the "post-placebo era", and a handy illustration for looking smart while you explain "double-dummy double-blind".