MTN 020 (ASPIRE)

To assess the safety and effectiveness of a silicone elastomer vaginal matrix ring containing dapivirine worn for a month at a time.

*Results released in February, 2016 found the dapivirine ring reduced the risk of HIV infection by 27 percent overall. Additional analysis released in July, 2016 found that among women who appeared to use the ring most regularly, HIV risk was cut by more than half across all analyses, and in some, by 75 percent or more.