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MTN 020 (ASPIRE)

Status
Completed
Phase
III
Principal Investigator(s)
Jared Baeten, Thesla Palanee
Objective


To assess the safety and effectiveness of a silicone elastomer vaginal matrix ring containing dapivirine worn for a month at a time.

Results released in February 2016: found the dapivirine ring reduced the risk of HIV infection by 27% overall. Additional analysis released in July 2016 found that, among women who appeared to use the ring most regularly, HIV risk was cut by more than 50% across all analyses, and for those who benefitted the most, by 75% or more.

Last updated October 20, 2022

July 2012
December 2015
Date of Enrollment Completion
July 3, 2015
Enrollment
3 540
18
Years
45
Years
Population
Women
Sites

Botha's Hill CRS

Westville, KwaZulu-Natal
South Africa

Chatsworth CRS

Chatsworth, KwaZulu-Natal
South Africa

Emavundleni (EMA) CRS

Cape Town
South Africa

eThekwini CRS

Durban, KwaZulu-Natal
South Africa

Isipingo CRS

Westville, KwaZulu-Natal
South Africa

Makerere University - Johns Hopkins University Research Collaboration

Kampala
Uganda

Seke South Clinical Research Site

Harare
Zimbabwe

Spilhaus Clinical Research Site

Harare
Zimbabwe

Tongaat CRS

Tongaat, KwaZulu-Natal
South Africa

Umkomaas CRS

Umkomaas, KwaZulu-Natal
South Africa

UNC Lilongwe CRS

Lilongwe
Malawi

Verulam CRS

Verulam, KwaZulu-Natal
South Africa

Wits Reproductive Health and HIV Institute (Wits RHI)

Johannesburg
South Africa

Zengeza 3 Clinic

Harare
Zimbabwe

Malawi College of Medicine John Hopkins University Clinical Research Site

Blantyre
Malawi