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Advances Towards Curing HIV-1 Infection From Tissue Reservoirs

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Published Research

Recent developments in immunotherapies and gene therapies provide renewed hope in advancing efforts towards a sterilizing or functional cure. On the horizon is research concentrated in multiple separate, but potentially complementary domains: vaccine research, viral transcript editing, T-cell effector response targeting including check point inhibitors, and gene editing. Here we review the concept of targeting the HIV-1 tissue reservoirs with an emphasis on the central nervous system and describe relevant new work in functional cure research and strategies for HIV-1 eradication.

November 6, 2019
Journal of Virology