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Antiretroviral Penetration Across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs

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For HIV cure strategies like “kick and kill” to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of 6 ARVs in 3 preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some – but not all - ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and clinical models.

October 14, 2019
Antimicrobial Agents and Chemotherapy