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Emerging Use of CRISPR Technology — Chasing the Elusive HIV Cure

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Published Research

Until recently, the efficiency of genetic editing was insufficient to have therapeutic potential for clinical applications. However, the development of artificial nucleases (a nuclease is an enzyme that cleaves the base pairs in RNA or DNA) that cut DNA at a desired site has solved the problem of gene-targeting efficiency. These tools include homing endonucleases, zinc finger nucleases, transcription activator–like effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9).

September 11, 2019
NEJM