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Simulated Vaccine Efficacy Trials to Estimate HIV Incidence for Actual Vaccine Clinical Trials in Key Populations in Uganda

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Published Research

HIV incidence was lower in simulated vaccine efficacy trials (SiVET) participants compared to non-SiVET. This difference was different for the two populations. Researchers designing HIV efficacy trials using observational cohort data need to consider the potential for lower than expected HIV incidence following screening and enrollment.

March 8, 2019