Towards a Dapivirine and Levonorgestrel Multipurpose Vaginal Ring: Investigations Into the Reaction Between Levonorgestrel and Addition-Cure Silicone Elastomers

With a dapivirine-releasing vaginal ring having successfully completed late-stage clinical testing for HIV prevention and currently undergoing regulatory review, there is now growing interest in next-generation multipurpose prevention technologies that seek to combine antiretroviral and contraceptive drugs within a single product. Here, we focus on ongoing efforts to develop a silicone elastomer vaginal ring releasing both dapivirine and levonorgestrel.