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Unintended HIV-1 Transmission to a Sex Partner in a Study of a Therapeutic Vaccine Candidate

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We report a case of sexual transmission of human immunodeficiency virus (HIV) that occurred during treatment discontinuation in a therapeutic vaccine trial, following oral sex. Transmission occurred even though the index participant was an HIV/AIDS activist, particularly well informed about the risks and modalities of transmission. This case report highlights the risk of secondary transmission of HIV during cessation of treatment in HIV cure–related trials.

February 16, 2019
Journal of Infectious Diseases