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Vaginal Microbiota and Mucosal Pharmacokinetics of Tenofovir in Healthy Women Using Tenofovir and Tenofovir/Levonorgestrel Vaginal Rings

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There were no significant correlations between the cervicovaginal aspirate concentration of TFV and the relative abundances of Gardnerella vaginalis or Prevotella species. Tissue concentrations of TFV-DP did not correlate with any the relative abundances of any species, including Gardnerella vaginalis. In conclusion, active IVRs did not differ from the placebo IVR on the effect on the vaginal microbiota. Local TFV and TFV-DP concentrations were high and similar among IVR users with Lactobacillus dominated microbiota versus CST IV vaginal microbiota.

May 20, 2019
PLoS One