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Trial Name Prevention Option Phase Start Date Sponsors Countries Population Candidate(s) Status
PURPOSE 2 PrEP III June 2021 Gilead Sciences United States of America Men, MSM, Transgender men, Transgender women Lenacapavir , F/TDF
Impower-024 PrEP III March 2021 Merck Sharp & Dohme Corp. Men, MSM, Transgender women Islatravir (MK-8591) Ongoing
Impower 022 PrEP III February 2021 Merck Sharp & Dohme Corp. United States of America, South Africa Women Islatravir (MK-8591), TDF/FTC (Truvada) Ongoing
SSPN formulations of novel emtricitabine PrEP Pre-clinical emtricitabine
Transdermal Delivery System for Tenofovir Alafenamide PrEP Pre-clinical Eastern Virginia Medical School, CONRAD, Corporation of Mercer University, USAID/PEPFAR F/TAF Stopped Early
CAPRISA 018 PrEP I January 2017 Centre for the Aids Programme of Research in South Africa; Stichting Amsterdam Institute for Global Health and Development; Université Jean Monnet, Saint-Etienne Women tenofovir Ongoing
MK-8591-016 PrEP II September 2019 United States of America, Malawi, South Africa, Israel Men Islatravir (MK-8591) Ongoing
CONRAD A15-140 Microbicides, PrEP I April 2016 United States of America Women TFV ring, TDF/FTC (Truvada) Completed
Implementation of the Pre-Exposure Prophylaxis (PrEP) to HIV in Brazilian transgender women (PrEParadas) PrEP Demo Project July 2018 Brazilian Ministry of Health Brazil Ongoing
MTN-041/ MAMMA Microbicides, PrEP Other May 2018 NIAID (DAIDS-ES: 38161) Malawi, South Africa, Uganda, Zimbabwe Women Dapivirine Ring, TDF/FTC (Truvada) Ongoing
PV1/PrEPVacc HIV Vaccine, PrEP IIb January 2020 Sponsor: Imperial College London. Coordinating partners: P Kaleebu, E Ruzagira (MRC/UVRI & LSHTM, Uganda); J Weber/J Fox/C Kingsley (Imperial College, UK); S McCormack (UCL, UK); K Chinyenze (IAVI-Kenya); G Pantaleo/S Ding (CHUV/EVF, Switzerland) Uganda, South Africa, United Republic of Tanzania, Mozambique Men, Women DNA , MVA, Protein Ongoing
CONRAD 137 PrEP I October 2016 Women F/TAF, TDF/FTC (Truvada) Completed
MTN 003D Microbicides, PrEP Other December 2012 MTN; NIAID (DAIDS-ES: 11893); NIH (5UM1AI068633) ; NICHD; NIMH South Africa, Uganda, Zimbabwe Women Completed
MTN-003C (VOICE Community Substudy) Microbicides, PrEP Other June 2010 DAIDS;NIH;NIAID South Africa Women Completed
HPTN 084 PrEP III October 2017 NIAID (DAIDS-ES: 38070), Viiv Healthcare, Gilead Botswana, Kenya, South Africa, Uganda, Zimbabwe, Swaziland, Malawi Women Cabotegravir (GSK 744), TDF/FTC (Truvada), F/TDF Ongoing
South Australian PrEP Demonstration Project PrEP Demo Project Australia Planned
Slovenian PrEP Demonstration Project PrEP Demo Project April 2017 Slovenia MSM Planned
Ireland Demonstration Project PrEP Demo Project December 2016 Ireland Planned
Sophocles - P4G PrEP Demo Project December 2016 Medical School of the University of Athens Greece MSM Ongoing
Bridge to Scale PrEP Other Kenya Women, MSM Planned

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