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MTN-043

Status
Planned
Phase
Open Label
Objective

MTN-043 is an open label, multi-site, mother-infant pair PK study designed to assess the PK of the dapivirine VR when used during breastfeeding. 

Prevention Option(s)
Microbicides
Arms and Assigned Interventions
Description
Approximately 100 healthy, HIV-uninfected breastfeeding women and their healthy infants between 6-12 weeks old (inclusive) will be enrolled in MTN-043. Enrolled maternal participants will be on study product for approximately 12 weeks, and enrolled mother-infant pairs will be followed up for up to three and a half months.
Mode of Delivery
Ring
Products
Dapivirine Ring
Enrollment
100
Population
Women
Sites

Blantyre CRS

Malawi

Shandukani

South Africa

MU-JHU Research Collaboration CRS

Kampala
Uganda

Zengeza CRS

Harare
Zimbabwe