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Status
Ongoing
Phase
Open Label
Principal Investigator(s)
Moses Kamya, MBChB, PhD, Maya Petersen, PhD
Objective

The SEARCH study aims to test evidenced-based innovative community based interventions that lead to the elimination of HIV in rural communities in East Africa using a multi-disease approach. The first phase of the study will quantify the health, economic and educational impact of early HIV diagnosis using a streamlined and immediate ART (antiretroviral therapy). This first phase will be completed in July 2017. The second phase of the study, will quantify the health, economic and educational impact of targeted Pre-Exposure Prophylaxis (PrEP), targeted HIV testing and targeted care interventions in the context of universal treatment and streamlined care. This second phase will be completed in July 2020. The study intervention is designed to improve the entire continuum of care, to reduce structural barriers for all populations including those most "at risk".

Prevention Option(s)
PrEP
Treatment
Study Design
Randomized
Open label
Arms and Assigned Interventions
Description
Intervention arm first phase: annual universal community-based HIV and multi-disease testing; ART for all HIV+ using streamlined care delivery Intervention arm second phase: baseline universal community-based HIV and multi-disease testing; ART for all HIV+ using streamlined care delivery + targeted PrEP, targeted HIV testing, and targeted care interventions
Products
TDF/FTC (Truvada)
ARMs
Experimental
Description
Intervention arm first phase: baseline community-based HIV and multi-disease testing Intervention arm second: baseline universal community-based HIV and multi-disease testing; ART for all HIV+ using streamlined care delivery
ARMs
Placebo Comparator
Trial Sponsors
University of California, San Francisco, IDRC, Makerere University, Kenya Medical Research Institute, Gilead Sciences, World Bank, NIAID, PEPFAR
April 2013
December 2018
Enrollment
340 000
Population
Women
Men
Sites

Nyanza Province

Kenya

Eastern Uganda

Mbale/Tororo region
Uganda

Southwestern Uganda

Mbarara region
Uganda