SEARCH

Status:Ongoing
Phase:Open Label
Principal Investigator(s):Moses Kamya, MBChB, PhD, Maya Petersen, PhD
Objective:The SEARCH study aims to test evidenced-based innovative community based interventions that lead to the elimination of HIV in rural communities in East Africa using a multi-disease approach. The first phase of the study will quantify the health, economic and educational impact of early HIV diagnosis using a streamlined and immediate ART (antiretroviral therapy). This first phase will be completed in July 2017. The second phase of the study, will quantify the health, economic and educational impact of targeted Pre-Exposure Prophylaxis (PrEP), targeted HIV testing and targeted care interventions in the context of universal treatment and streamlined care. This second phase will be completed in July 2020. The study intervention is designed to improve the entire continuum of care, to reduce structural barriers for all populations including those most "at risk".
Prevention Option(s):PrEP, Treatment U=U
Study Design:Open label, Randomized
Arms and Assigned Interventions
DescriptionIntervention arm first phase: annual universal community-based HIV and multi-disease testing; ART for all HIV+ using streamlined care delivery Intervention arm second phase: baseline universal community-based HIV and multi-disease testing; ART for all HIV+ using streamlined care delivery + targeted PrEP, targeted HIV testing, and targeted care interventions
Mode of Delivery
ARMsExperimental
Official Code: NCT01864603
Trial Sponsors: Gilead, IDRC, Kenya Medical Research Institute, Makerere University, NIAID, PEPFAR, University of California San Francisco, World Bank
Start Date
End Date
April 30, 2013
December 31, 2018
Enrollment:340,000
Age range: ↔ any
Population:Cisgender Men, Cisgender Women