P-Values

Discover perspectives on the latest findings, biggest challenges and most exciting successes in our collective work.

At P-Values, you’ll find updates, perspective, insights and information from staff and partners working on the frontlines of research, advocacy and implementation. P-value is a statistical term for the probability that a trial result is reliable and not the outcome of chance. 

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Global Health Watch: PEPFAR Reemerges, Budget Deadlines, Gov’t Shutdown Risks, Vaccine Policy Unraveling and What’s Next for FY26

Congress faces a looming deadline to avert a government shutdown if they cannot agree to a bipartisan fiscal year 2026 federal budget. In this context, the FY26 appropriations process, the President’s request for “pocket rescissions” to claw back Congressionally appropriated funds, AVAC’s court case, and PEPFAR’s reemergence to rollout long-acting PrEP take on heightened urgency.

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Global Health Watch: PEPFAR Reemerges, Budget Deadlines, Gov’t Shutdown Risks, Vaccine Policy Unraveling and What’s Next for FY26

Congress faces a looming deadline to avert a government shutdown if they cannot agree to a bipartisan fiscal year 2026 federal budget. In this context, the FY26 appropriations process, the President’s request for “pocket rescissions” to claw back Congressionally appropriated funds, AVAC’s court case, and PEPFAR’s reemergence to rollout long-acting PrEP take on heightened urgency.

September 2025

A Resource Round Up Covering Funding Fights & A New Generation of PrEP

The news is moving fast, and the need for advocacy is moving even faster. AVAC is providing resources, updates on its fight against the US government on the foreign aid freeze, documenting impacts on STI prevention, and sharing new opportunities for education and advocacy in HIV prevention.

September 2025

Global Health Watch: CDC leaders depart, updates in the AVAC v Department of State case on foreign aid

This week, political overreach that is destabilizing global health programs and policy was on full display with the political interference and departure of leaders at the US Centers for Disease Control and Prevention (CDC) and the US Administration’s emergency appeal to the Supreme Court in AVAC v. Department of State case.

August 2025

AVAC Responds to Government’s Emergency Appeal to SCOTUS

In response to the US government’s August 26 emergency application to the US Supreme Court seeking to stay the preliminary injunction in the AVAC v Department of State legal case against the foreign aid freeze, AVAC’s Executive Director, Mitchell Warren, asks whether SCOTUS will restore some of the checks and balances this administration is consistently undermining.

August 2025

The EXPrESSIVE Trials Test a Monthly Pill for PrEP: Advocates speak

The drug maker Merck’s recent announcement of two new efficacy trials of a monthly PrEP pill, known as the EXPrESSIVE program, is welcome news. In addition, Merck’s robust commitment to stakeholder engagement to date contributes an important model of Good Participatory Practice (GPP) to the field, by putting global advocates at the forefront of planning for the program.

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August 2025

Global Health Watch: Pullback at UNGA, foreign aid freeze litigation, FY26 budget cuts and new NIH research priorities

This week brought another round of threats and attacks on US global health policy including troubling court rulings over the foreign aid freeze, deepening cuts to the fiscal year 2026 (FY26) global health budget, and troubling developments at NIH, where new research priorities and another agency-wide review could disrupt HIV and global health research. We also track new signals of a US pullback at UN General Assembly (UNGA).

August 2025

Global Health Watch: NIH swings to implementation science, Court upholds foreign aid freeze, federal grants politicized & violence at US CDC

This issue covers the Appeals Court opinion in AVAC v Department of State, a violent attack on the CDC fueled by vaccine disinformation, the continued dismantling of the NIH with a potential pendulum swing toward implementation science and away from basic science and clinical research, and a new executive order politicizing federal grants.

August 2025

AVAC Condemns Appeals Court Reversal of Order Directing Trump Administration to Spend Foreign Assistance Funds

AVAC strongly condemns today’s decision by the U.S. Court of Appeals for the D.C. Circuit to overturn the District Court’s injunction that compelled the restoration of vital foreign aid funding in the lawsuit, AVAC v. United States Department of State, which challenged the Trump Administration’s funding freeze on foreign assistance.

August 2025

Global Health Watch: mRNA vax contracts cancelled, Gates Foundation commits to women’s health R&D, SA invests in research

This week the US administration cancelled $500 million in mRNA vaccine contracts while a Government Accountability Office investigation found the NIH grant freezes violated the law. The Gates Foundation committed $2.5 billion to women’s health R&D, and South Africa is investing to protect its national research capacity in the face of US funding cuts.

August 2025

Key Takeaways from the STI & HIV 2025 World Congress

The STI & HIV World Congress brought together over 1,400 researchers, healthcare providers, advocates, funders and more in Montreal last week, where they shared urgent insights, promising innovations, and calls to action. The gathering came at a pivotal moment when rates of STIs are rising globally, amid massive disruptions caused by shifts in US policies and funding and decreased investments from other funders.

August 2025

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P-Values Blog

Discover perspectives on the latest findings, biggest challenges and most exciting successes in our collective work.

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