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P-Values
Discover perspectives on the latest findings, biggest challenges and most exciting successes in our collective work.
At P-Values, you’ll find updates, perspective, insights and information from staff and partners working on the frontlines of research, advocacy and implementation. P-value is a statistical term for the probability that a trial result is reliable and not the outcome of chance.
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Moving the STI Research, Development and Diagnostics Agenda Forward
The global burden of STIs is staggering with more than one million treatable STIs being acquired daily, and new threats like antibiotic-resistant gonorrhea and rising syphilis cases demanding urgent action. Yet funding, research, and political attention lag far behind the need.
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PxWire is Out!
This issue provides a range of maps to help orient the field on critical HIV prevention activities: the status of delivering injectable cabotegravir (CAB for PrEP); funders and countries on track for early introduction of injectable lenacapavir (LEN for PrEP); and where new Phase 3 efficacy trials testing MK-8527 as a monthly pill for PrEP are taking place.
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Global Health Watch: Development finance, impact of foreign aid cuts + new PrEP resources to track PrEP access, pricing and the pipeline
This week major shifts in development finance make headlines as do the real-time consequences of the US cuts to foreign aid and withdrawing from the WHO. AVAC’s new issue of PxWire amplifies issues of access, equity, and accountability with an...
Moving the STI Research, Development and Diagnostics Agenda Forward
The global burden of STIs is staggering with more than one million treatable STIs being acquired daily, and new threats like antibiotic-resistant gonorrhea and rising syphilis cases demanding urgent action. Yet funding, research, and political attention lag far behind the need.
PxWire is Out!
This issue provides a range of maps to help orient the field on critical HIV prevention activities: the status of delivering injectable cabotegravir (CAB for PrEP); funders and countries on track for early introduction of injectable lenacapavir (LEN for PrEP); and where new Phase 3 efficacy trials testing MK-8527 as a monthly pill for PrEP are taking place.
Global Health Watch: US CDC layoffs, CIFF funding cuts to NGOs + call for streamlined global health architecture at World Health Summit
The US government shutdown escalated this week as the Administration laid off thousands of workers before chaotically retracting many of these notices. The UK-based Children’s Investment Fund Foundation (CIFF) abruptly cut all funding to US-based NGOs, and world leaders urged a streamlined global health system amid funding cuts.
Global Health Watch: US shutdown continues, WHO prequalifies lenacapavir, NIH recompetes AIDS networks
As the US government is in its second week of being shut down, the ripple effects across global health shows the interconnectedness of the public health infrastructure in the US and globally and uncertainty about the future of foreign aid. Amid this turmoil, the World Health Organization has prequalified injectable lenacapavir for PrEP in record time, using a new, expedited process.
New LEN Resources, Publications on PLP and TG Inclusion and More!
This roundup from AVAC highlights key developments across the field of HIV prevention from accelerating access to lenacapavir, to advancing inclusion of pregnant and lactating people, and trans and gender-diverse communities in research.
Inclusion Made Simple, In Difficult Times
This is not the time to scrub tran and gender diverse people inclusion from HIV trial designs and protocols. Now is the moment to use everything at our disposal to set in motion an era of HIV research that meaningfully responds to this community’s needs.
Global Health Watch: US government shuts down, foreign aid funding expires, Jeanne Marrazzo fired from NIH, issue 36
The US government shutdown that began at midnight on October 1 has stalled key public health operations just as the Supreme Court issued a ruling in AVAC v. Department of State that allowed $4 billion dollars in foreign aid to expire, eroding both health and human services and constitutional checks and balances. Meanwhile, Jeanne Marrazzo was officially fired as Director of NIAID, underscoring how politically motivated attacks on science are dismantling the infrastructure that has underpinned decades of progress in HIV prevention and research.
Prevention Option:
US Supreme Court Gives the Administration a Free Pass to Withhold Foreign Aid
Late today in AVAC v Department of State and Global Health Council v Trump, the Supreme Court of the United States granted the US Presidential Administration’s request to stay an injunction that would require the Administration to obligate $4 billion of foreign assistance funds before they expire on September 30, as required by law. The Court’s ruling temporarily grants the Administration’s request to pause a lower court order that the government spend the funds. With just four days until September 30, those funds, which otherwise would have saved lives and advanced global health and national security, will remain unspent.
Prevention Option:
Global Health Watch: A generic price for LEN, Future of UNAIDS, UNGA 80, AI for Health, Issue 35
The stakes are high as the US approaches the start of a new fiscal year (FY26) on October 1, currently mired in stalled White House negotiations and a looming government shutdown; the Supreme Court’s pending decision on AVAC’s lawsuit; and the new US “America First” strategy to reshape foreign aid. This issue highlights major global health developments at the UN General Assembly, from debate over the future of UNAIDS to commitments from the Gates Foundation and Unitaid to accelerate access to injectable lenacapavir for PrEP (LEN), alongside new discussions on AI ethics and health.
Prevention Option:
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P-Values Blog
Discover perspectives on the latest findings, biggest challenges and most exciting successes in our collective work.
Advocates Network
AVAC’s email list for organization and individuals interested in timely updates and critical perspectives on developments in biomedical HIV prevention.
Weekly News Digest
A comprehensive round-up of HIV prevention media coverage and scientific publications.
PxPulse
Each month this podcast uses interviews, discussion and first-person reflections to explore vital topics confronting the field of HIV prevention research.
PxWire
PxWire is AVAC’s quarterly update on biomedical HIV prevention. Each issue highlights key developments, challenges and opportunities, and features a centerspread infographic that provides a visual tool for framing these issues.
Pandemic Watch
Pandemic Watch is a curated news digest on the latest pandemic prevention, preparedness, and response (PPPR) news and resources.
Press Releases
A collection of official statements from AVAC.
AVAC in the News
Media clippings featuring AVAC, its staff and close partners in the news media.