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Combination Prevention

Expanded high-impact prevention is needed to bring the epidemic to a conclusive end.

Combination or high-impact prevention is a set of strategically-selected interventions that matches the needs of a given country or community—and is delivered at the scale needed to make an impact. It means doing less of something and far more of others. It means making tough decisions and measuring impact. Above all, it means moving with clarity and speed.

There are emerging global definitions of what combination prevention is, and evolving models of what it can achieve. AVAC works with advocates to define what combination prevention means in a given context, track country and donor alignment with a combination prevention strategy and ensure that there is an implementation science agenda to fill in gaps in knowledge. To learn more about combination prevention in general and our work in particular visit the links below:

What We're Reading

HIV Combination Prevention Associated with Sharp Drop in Diagnoses

A combination of HIV prevention methods—including pre-exposure prophylaxis (PrEP), early HIV diagnosis through frequent testing and timely antiretroviral therapy for treatment as prevention – was associated with a sharp drop in HIV transmission among gay, bisexual and other men who have sex with men, a new study found.

August 31, 2021
Combination Prevention
Contagion Live

Trial Designs for Evaluating Combination HIV Prevention Approaches

The multi-arm design is useful for evaluating single factor regimens, while the all-in-one and factorial designs are sensitive in assessing the overall efficacy when there is interest in combining individual component regimens anticipated to have complementary mechanisms. The factorial design is a preferred approach when assessing combination regimens due to its favorable power properties and since it is the only design providing direct insights about the contribution of individual components to the combination approach’s overall efficacy and about potential interactions.

July 23, 2020
Combination Prevention, Male and Female Condoms, PrEP, Treatment
HIV Research & Clinical Practice
Featured Resources

AVAC Report 2019: Now What?

At the threshold of 2020, it’s clear that global goals for HIV prevention will miss the mark by a long shot. Though important progress has been made, the crisis UNAIDS called out in 2016 persists today with new infections around 1.7 million annually, a far cry from the 2020 target of fewer than 500,000. So, we asked ourselves, Now What?, and answered with cross-cutting analysis and an advocacy agenda to match.

November 2019
AVAC
HIV Vaccine, Combination Prevention, Male and Female Condoms, Cure, Hormonal Contraceptives and HIV, Microbicides, Multipurpose Prevention Technologies, PrEP, Treatment, Voluntary Medical Male Circumcision
AVAC Report
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