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Microbicides

The term “microbicide” refers to substances being studied that could be used in the vagina and/or rectum to reduce the risk of HIV infection via sexual exposure. Today, daily oral PrEP is the only HIV prevention tool for women that does not require partner negotiation at or around the time of sex. Access to PrEP is expanding, but more options are needed. Easy-to-use microbicides would fill an important HIV prevention need. They can be used discreetly and their effect is localized to the site of infection (the rectum or vagina) and not systemic (affecting the whole body), characteristics some people will prefer.

A range of microbicide strategies are under investigation, including gels, douches and the dapivirine vaginal ring, which is being considered for licensure. Developed by the International Partnership for Microbicides (IPM), the ring would be the first microbicide and the next prevention tool available since oral PrEP’s approval in 2012. For the latest developments in dapivirine ring research and plans for potential rollout, visit the dapivirine ring page on PrEP Watch.

Key Update

The ring is a female-initiated option to reduce the risk of HIV infection. The ring must be worn inside the vagina and is made of silicone and is easy to bend and insert. The ring works by releasing the antiretroviral drug dapivirine from the ring into the vagina slowly over 28 days.

January 26, 2021
World Health Organization
What We're Reading

You guessed it right. I am talking about the Dapivirine Vaginal Ring (DPV-VR), which is one of the top advances happening in the field of microbicides. It is the first long acting prevention product whose Phase-3 randomised controlled studies have shown that using the Dapivirine Vaginal Ring reduced the risk of HIV infection in women and long-term use was well-tolerated.

January 28, 2021
CNS

There's a vaginal ring on the market that is making headlines, and it's not just for being a contraceptive. The dual-purpose ring, this 90-day vaginal ring is gaining the spotlight in preventative measures for pregnancy and for pregnancy and HIV, which is a first for a vaginal ring.

January 26, 2021
Babygaga
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