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Px Pulse

Px Pulse is a project of AVAC and our partners in the Coalition to Accelerate and Support Prevention Research. Each month this podcast uses interviews, discussion and first-person reflections to explore vital topics confronting the field of HIV prevention research.

Px Pulse features in-depth conversations with voices across the field. For a quick take, listen to highlighted selections from those interviews.

We're very interested to hear your thoughts!


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AVAC Report 2018 & HIV R4P (19:06)
October 18, 2018
In this episode of Px Pulse, Ntando Yola, a veteran advocate and part of the Coalition to Accelerate and Support Prevention Research (CASPR) shares his advocacy priorities for R4P and beyond. But first, AVAC’s Emily Bass talks about the just-launched 2018 annual report from AVAC, this year titled No Prevention, No End!

Combination Prevention and AIDS 2018 (20:57)
August 29, 2018
In this episode, featuring Ambassador Deborah Birx, we take a look at one area of great importance that was center stage at last month’s AIDS 2018 conference in Amsterdam: primary prevention.

Cure Research and Analytic Treatment Interruption (25:45)
June 28, 2018
In this episode of Px Pulse, researchers and advocates debate the rationale, risks and ethics of interrupting treatment as part of cure research. This is known as analytic treatment interruption or ATI.

HIV Vaccine Science, Research, Updates and Advocacy (27:11)
May 31, 2018
With HIV Vaccine Awareness Day (HVAD) in the spotlight earlier this month, AVAC’s May episode of Px Pulse features four experts steeped in HIV vaccine research. Together they help set expectations for where the field is now and where it is going.

From the Trenches, Advocates Share Their Prevention Priorities (16:38)
April 30, 2018
In this episode, we bring you two different conversations, each throwing a spotlight on different aspects of HIV prevention advocacy today. You'll hear how the AVAC Partner Forum brought key issues into focus and how these advocates are sharpening their strategies. Then we turn to a global effort to accelerate prevention.

What's Next for the Dapivirine Ring (30:40)
March 30, 2018
In this episode of Px Pulse, Zeda Rosenberg of the International Partnerships for Microbicides explains the latest findings and spells out how, when, where and if the ring might become an available tool. A trial participant and community leader in Uganda pulls back the curtain on the ups and downs of using the ring, and a Ugandan investigator with the REACH study, Carolyne Akello of the Makere University-Johns Hopkins University Research Collaboration, explains the importance of this trial, the next step in testing the potential of this monthly vaginal ring for young women.

Three Perspectives, Two Trials and One Big Goal (16:42)
February 26, 2018
With more efficacy trials underway today than ever before in HIV prevention research, this episode zooms in on two that have most recently launched: one of two trials testing a long-acting injectable antiretroviral called cabotegravir (HPTN 084), and the study of a "mosaic" vaccine developed by Janssen Pharmaceuticals (HVTN 705/HPX2008).

2018 and HIV Prevention: AVAC's Take (8:04)
January 10, 2018
In this episode hear about recently published findings from a study out of Rakai, Uganda confirm that scaling up of a combination of existing interventions, such as voluntary medical male circumcision and antiretroviral therapy provides protection from HIV at the population-level. How do we apply these findings at the global level? How should advocates prepare for results—anticipated in 2019—of the ECHO trial that’s looking at the effect of hormonal contraceptives on HIV risk? And what needs to happen in 2018 to reach long-term global targets for ending the epidemic?

What’s the State of the Field? AVAC Report 2017 (14:34)
December 19, 2017
In this month's episode of Px Pulse, AVAC's Diretor of Strategy & Content Emily Bass shares highlights from our annual report, Mixed Messages and How to Untangle Them, and calls for action on the unfinished work of scaling up prevention.

Standard of Care in the Era of PrEP (18:07)
November 22, 2017
Every research trial of a new HIV prevention option offers a package of services to protect participants from HIV. This standard of care is essential to the design of an ethical trial.

Trial Trial Again: Getting research right for adolescents (11:28)
October 12, 2017
Both research and advocacy for HIV prevention are intensifying their focus on young people. Bringing interventions that work for this population holds unique challenges. AVAC’s Manju Chatani-Gada explores how and why prevention research must reach the next generation.

Testing Long-Acting PrEP, Easier Said Than Done (11:56)
October 12, 2017
Leading researcher Dr. Deborah Donnell tells us why the HIV Prevention Trials Network (HPTN) changed the design of one of two trials testing long-acting cabotegravir, as an injectable PrEP.

PrEP and Trial Design — A no brainer for some (6:15)
September 22, 2017
Slim Abdool Karim, co-principal investigator of the landmark CAPRISA 004 study, talks about why designing trials with oral PrEP is a must—scientifically and ethically.

Golden Age or Fools Gold? (3:26)
September 13, 2017
Carl Dieffenbach, Director of NIH’s Division of AIDS, tells AVAC where he sees the most promise in the field of HIV prevention and what it will take to “put out the fire.”