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Trial Name Prevention Option Phase Start Date Sponsors Countries Population Candidate(s) Status
DREAM-01 Microbicides, Multipurpose Prevention Technologies I October 2016 NIAID (DAIDS-ES: 12067) United States of America, Malawi Men Ongoing
MTN 042 Microbicides III NIAID (DAIDS-ES: 38544) Malawi, South Africa, Uganda, Zimbabwe Pregnant women, Women Dapivirine Ring, TDF/FTC (Truvada) Ongoing
MTN 003D Microbicides, PrEP Other December 2012 MTN; NIAID (DAIDS-ES: 11893); NIH (5UM1AI068633) ; NICHD; NIMH South Africa, Uganda, Zimbabwe Women Completed
MTN-003C (VOICE Community Substudy) Microbicides, PrEP Other June 2010 DAIDS;NIH;NIAID South Africa Women Completed
MTN 003B Microbicides IIb November 2009 NIAID, MTN Zimbabwe, Uganda Women TDF/FTC (Truvada) Completed
TRIO Study (Tablets, Rings, and Injectables as Options for women) Microbicides, Multipurpose Prevention Technologies Other November 2014 Bill & Melinda Gates Foundation (OPP1114942) Kenya, South Africa Women Completed
EMOTION - Enhancing Microbicide Uptake in High-Risk End Users Microbicides, PrEP Other July 2016 USAID, CONRAD Kenya, South Africa, Zimbabwe Women Ongoing
MTN 038 Microbicides I December 2018 NIAID (DAIDS-ES: 38460) United States of America Women TFV ring Ongoing
MTN-039 Microbicides, Multipurpose Prevention Technologies Open Label, I December 2019 MTN United States of America Men, Women Elvitegravir (EVG) Ongoing
Safety and Pharmacokinetic Study of HIV Prophylaxis Using Antiretroviral Intravaginal Rings in Healthy Women Microbicides Open Label June 2015 Auritec Pharmaceuticals (ARV-IVR 01) United States of America TDF, TDF/FTC (Truvada), Maraviroc Completed
Safety and Pharmacokinetics (PK) of a Polyurethane Tenofovir Disoproxil Fumarate (TDF) Vaginal Ring (TDF IVR-002) Microbicides I January 2017 Albert Einstein College of Medicine of Yeshiva University United States of America, Kenya Women TDF Stopped Early
The Quatro Study Microbicides Open Label November 2015 CONRAD South Africa, Zimbabwe Women Completed
Safety and Pharmacokinetic Study of Oral Maraviroc and Maraviroc 1% Gel in HIV-1 Seronegative Adults (CHARM-03) Microbicides I January 2015 IPM, NIAID, NIH United States of America Women, Men Maraviroc Completed
CONRAD 128 Microbicides, Multipurpose Prevention Technologies I October 2014 CONRAD (A13-128) Dominican Republic, United States of America Women tenofovir, Levonorgestrel Completed
Film Antiretroviral Microbicide Evaluation (FAME-02) Microbicides I August 2012 IPM United States of America Women dapivirine gel Completed
Comparison of Tenofovir Vaginal Gel and Film Formulations (FAME-05) Microbicides Open Label November 2014 CONRAD Women 1% tenofovir gel, tenofovir Completed
A Phase I Trial to Assess the Safety of Tenofovir Gel and Film Formulations: FAME 04 Microbicides, Multipurpose Prevention Technologies I November 2013 CONRAD United States of America Women 1% tenofovir gel, HEC gel, tenofovir Completed
Pre-exposure prevention of viral entry (PREVENT) Microbicides Pre-clinical January 2014 NIH, NIAID United States of America GRFT
IPM 020 Microbicides II, I June 2009 IPM United States of America Women dapivirine gel Completed
IPM 014B Microbicides II, I July 2009 South Africa Women dapivirine gel Completed

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