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HPTN 071 (PopART)

Status
Completed
Phase
Open Label
Principal Investigator(s)
Helen Ayles & Nulda Beyers
Objective

HPTN 071 (PopART) is a study that will find out whether offering a combination of several already known HIV prevention methods to a community will better prevent the spread of HIV than offering them inidvidually. The study will be conducted in Zambia and South Africa. 

 


Results: CROI Mar. 5, 2019-- Findings from HPTN 071 (PopART) show delivery of an HIV prevention strategy that includes offering in-home HIV testing to everyone, with immediate referral to HIV care, and treatment for people living with HIV based on prevailing in-country guidelines, can substantially reduce new HIV infections. 

Prevention Option(s)
Combination Prevention
Treatment
Study Design
Randomized
Open label
Arms and Assigned Interventions
Description
Universal Testing with Immediate ART: House-to-house deployment of: Universal HIV counseling and testing; Active linkage to care for individuals diagnosed as HIV-infected, with immediate eligibility for ART; Promotion of male circumcision and prevention of mother to child transmission (PMTCT) services; Provision of condoms; Strengthening of HIV testing and services at health facilities and other venues; Strengthening of male circumcision and prevention of mother-to-child transmission of HIV services available in the community; and Treatment of sexually transmitted infections (STIs) and provision of condoms at health units
ARMs
Experimental
Description
Universal Testing with ART with National Guideline Eligibility: House-to-house deployment of: Universal HIV counseling and testing; Active linkage to care for individuals diagnosed as HIV-infected, with ART eligibility according to national guidelines; Promotion of male circumcision and PMTCT services; Provision of condoms; Strengthening of HIV testing and services at health facilities and other venues; Strengthening of male circumcision and PMTCT services available in the community; and Treatment of STIs and provision of condoms at health units.
ARMs
Experimental
Description
Standard of Care: Strengthening of HIV testing and ART services according to national guidelines at health facilities and other venues; Strengthening of male circumcision and PMTCT services available at health facilities and other venues in the community; and Treatment of STIs and provision of condoms at health facilities and other venues in the community.
ARMs
Placebo Comparator
Trial Sponsors
NIAID, NIMH, NIDA, Office of the U.S. Global AIDS Coordinator, Bill & Melinda Gates Foundation, & NIH
August 2013
August 2017
18
Years
44
Years
Population
Women
Men
HIV positive
Sites

Desmond Tutu Clinical Research Center

Cape Town, South Africa
South Africa

Zambart

Lusaka
Zambia