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A cure for HIV infection is one of the ultimate long-term goals of research today. The science is expanding, raising hopes and challenges.

The term “cure” refers to a strategy or strategies that would eliminate HIV from a person’s body, or permanently control the virus and render it unable to cause disease. A range of types of cures are being discussed today. A “sterilizing” cure would completely eliminate the virus. A “functional” cure would suppress HIV viral load, keeping it below the level of detection without the use of ART. The virus would not be eliminated from the body but would be effectively controlled and prevented from causing any illness. The term “remission” is also used and it means the virus is undetectable using the most sensitive tests but could return because small numbers of copies remain. It’s important to know that researchers are still figuring out exactly how to define these types of HIV cures. Although some possible cases of functional cures have been reported, it takes time to be certain that HIV can no longer cause disease, because it is known that even very low levels of virus can increase the risk of certain illnesses and ultimately lead to AIDS.

The cure strategies currently under investigation are, in many cases, potentially toxic and carry risks for people undergoing them. Figuring out how to communicate the risks and benefits of cure strategies to potential trial participants will be an important part of any cure clinical trial. In order to test whether a person has been cured, they need to stop effective antiretroviral treatment so that viral rebound, if any, can be measured. There are no standardized guidelines for how to time such “treatment interruptions” so that they minimize risks for cure trial participants. Finally, cure strategies may look different for men, women and children—biological differences between sexes and differences in adult versus pediatric immune systems mean that it is unlikely there will be a “one size fits all” cure approach. AVAC is working with partners to track, translate and accelerate cure research.

What We're Reading

There are many possibilities to further increase the potential efficacy of bnAbs. Most notably, Fc domain engineering to improve half-life and increase engagement of effector cells will augment two advantages of bnAbs. Moreover, antibody engineering can improve affinity and recognition of conserved epitopes and allows the combination of multiple epitope specificities in a single molecule. These increasingly potent and broad antibodies may prove valuable as alternative HIV-1 therapeutic and possibly in curative approaches.

October 1, 2019
Antibody Related Research, Cure
Current Opinion in Virology

The landscape of HIV treatment continues to shift and grow, with new and streamlined therapies introduced on a regular basis. People living with HIV today can lead very different lives than those of people who were diagnosed in the ’90s and early 2000s. Antiretroviral therapy (ART) makes it possible for a person living with HIV to experience complete viral suppression, even engaging in condomless sexual intercourse, or gestating a baby without fear of passing on the virus (Undetectable=Untransmittable).

May 24, 2019
Contagion Live

For just the second time since the global epidemic began, a patient appears to have been cured of infection with HIV, the virus that causes AIDS.

March 4, 2019
New York Times
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