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Cure

A cure for HIV infection is one of the ultimate long-term goals of research today. The science is expanding, raising hopes and challenges.

The term “cure” refers to a strategy or strategies that would eliminate HIV from a person’s body, or permanently control the virus and render it unable to cause disease. A range of types of cures are being discussed today. A “sterilizing” cure would completely eliminate the virus. A “functional” cure would suppress HIV viral load, keeping it below the level of detection without the use of ART. The virus would not be eliminated from the body but would be effectively controlled and prevented from causing any illness. The term “remission” is also used and it means the virus is undetectable using the most sensitive tests but could return because small numbers of copies remain. It’s important to know that researchers are still figuring out exactly how to define these types of HIV cures. Although some possible cases of functional cures have been reported, it takes time to be certain that HIV can no longer cause disease, because it is known that even very low levels of virus can increase the risk of certain illnesses and ultimately lead to AIDS.

The cure strategies currently under investigation are, in many cases, potentially toxic and carry risks for people undergoing them. Figuring out how to communicate the risks and benefits of cure strategies to potential trial participants will be an important part of any cure clinical trial. In order to test whether a person has been cured, they need to stop effective antiretroviral treatment so that viral rebound, if any, can be measured. There are no standardized guidelines for how to time such “treatment interruptions” so that they minimize risks for cure trial participants. Finally, cure strategies may look different for men, women and children—biological differences between sexes and differences in adult versus pediatric immune systems mean that it is unlikely there will be a “one size fits all” cure approach. AVAC is working with partners to track, translate and accelerate cure research.

Key Update

Are you an HIV advocate or peer educator working in a resource-limited setting? Are you interested in HIV cure-related advocacy? Are you interested in strengthening your understanding of the latest HIV cure research?

The International AIDS Society (IAS) and AVAC invite you to apply for a fellowship to attend an interactive three-day workshop in Uganda on HIV cure research literacy and advocacy.

February 22, 2018
International AIDS Society and AVAC
What We're Reading

Very early HIV treatment in infants is feasible and safe and leads to a small reservoir of infected cells, two studies from Botswana and Thailand show. The findings offer hope that infants diagnosed and treated soon after birth will have a better chance of controlling HIV if future research leads to interventions that can control HIV without prolonged treatment – a so-called functional cure.

March 13, 2018
aidsmap

Despite enormous efforts over more than 30 years, HIV/AIDS researchers have yet to develop either a vaccine or cure for the disease. But they have made progress in monkey experiments, and two studies reported here this week at the largest annual U.S. HIV/AIDS conference created serious buzz.

March 9, 2018
Science Magazine

The January issue of AIDS Research and Human Retroviruses covers all things cure. Articles include a look at current challenges related to eradicating HIV from tissue reservoirs, innovative approaches to imaging that may guide new discoveries, a crowdsourced study from China on attitudes toward a cure and much more!

January 1, 2018
AIDS Research and Human Retroviruses
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