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HIV Vaccine

An HIV vaccine is imperative for an enduring end to the epidemic.

An effective preventive HIV vaccine would teach the body how to prevent HIV infection. Vaccines are the most powerful public health tool—and an HIV vaccine would play an essential role in ensuring the end to the AIDS epidemic.

While effective vaccines remain years away, there are more reasons for hope than ever before. HIV vaccine research is more productive than ever, with multiple large-scale vaccine trials underway and dozens of vaccine approaches in development.

Key Update

AVAC HIV Vaccine: The challenges ahead

Because recent results from major HIV vaccine trials have had disappointments and reframed the questions the field must ask, AVAC hosted a 2022 webinar series on the progress in HIV vaccines in light of a rapidly changing research landscape.

September 28, 2022
HIV Vaccine
What We're Reading

First In-Africa Clinical Trial of mRNA HIV Vaccine

Though not for lack of effort, there remains a significant need for an HIV vaccine. Today, Moderna and the International AIDS Vaccine Initiative (IAVI) announced the first in-Africa clinical trial for an HIV vaccine candidate.

May 18, 2022
HIV Vaccine
Contagion Live

HIV Vaccines in 2022: Where to From Here?

For over 2 years, the world has been riveted by progress and pitfalls of the COVID-19 pandemic and subsequent vaccine development and rollout. However, alongside scientific milestones of COVID-19 vaccines, there have been significant results from HIV vaccine and antibody-mediated prevention trials. These include the first proof of concept of HIV prevention from passive antibodies and recent insights on the possibility of germline targeting and the mRNA platform towards an effective HIV vaccine.

May 17, 2022
HIV Vaccine
JIAS

Preparing Society for a HIV Vaccine

At a 2016 workshop in Chennai to understand people’s hope for a human immunodeficiency virus (HIV) vaccine, a participant said such a vaccine may make society more “morally corrupt”. He believed that a preventive vaccine may encourage more people to engage in unsafe sex with multiple partners. The respondent had HIV and had experienced stigma and discrimination.

May 16, 2022
HIV Vaccine
Nature

New Study Tests Three mRNA HIV Vaccine Candidates

A new clinical trial testing experimental HIV vaccines that use the same messenger RNA (mRNA) technology as highly effective COVID-19 vaccines is now underway. The three vaccine candidates deliver different versions of HIV spike proteins, which the virus uses to enter cells.

March 16, 2022
HIV Vaccine
POZ
Featured Resources

Phase 1 mRNA HIV Vaccine Trials

A snapshot of early phase trials testing mRNA-based HIV vaccines.

May 2022
AVAC
HIV Vaccine
Fact Sheet

Experimental Medicine Vaccine Trials (EMVTs): Opportunities and Challenges

A look at an innovative trial design to safely speed the discovery of viable vaccine candidates. The focus of EMVTs is to accelerate vaccine science rather than progress individual products.

May 2022
AVAC
HIV Vaccine
Fact Sheet
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