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PrEP

PrEP works. Investment in more options must continue, and faster, smarter rollout must be a top priority.

Clinical trials have shown that different types of pre-exposure prophylaxis (PrEP) using antiretroviral (ARV) drugs dramatically reduce the risk of HIV infection for people who take it as directed. While PrEP won’t be right for every individual at risk for HIV, millions will benefit—if they can access this potentially life-saving option.

So far, PrEP’s implementation has been piecemeal. Meanwhile the landscape is changing as more options move through research, regulatory review or enter the market, intensifying the need to improve implementation.

TDF/FTC (brand name Truvada) was first approved for use as oral PrEP in 2012, now dozens of countries have approved it, but PrEP still has not reached many of the people who need it most. In 2019, F/TAF (brand name Descovy) became the 2nd oral PrEP product to be approved, but only for men who have sex with men (MSM) and transgender women. Efficacy studies of F/TAF among cisgender women are ongoing. Findings reported in 2020 show injectable cabotegravir is safe and effective and the product is undergoing regulatory review. For more information go to our dedicated pages on cabotegravir on AVAC.org and PrEPWatch.

For all these interventions and other ARVs still in the R&D pipeline, advocacy is crucial: There must be continued investment in the development of additional options, community engagement must be integrated from trial design to implementation, and improved programming must support those who need HIV prevention options the most.

Key Update

Over the weekend, we at AVAC and allies around the world witnessed history and gained hope as the results of the American presidential election (finally) got announced. News also came in that the HPTN 084 trial of injectable long-acting cabotegravir for HIV prevention in cisgender women found a high level of effectiveness at a scheduled interim data review.

November 9, 2020
AVAC
What We're Reading

An experimental islatravir implant that can be replaced just once a year could one day be a convenient new option for HIV pre-exposure prophylaxis (PrEP), according to early study results presented this week at the virtual Conference on Retroviruses and Opportunistic Infections (CROI).

March 10, 2021
POZ

When Wasiu spoke to Devex in 2018 about his HIV-positive status and the statuses of his three wives, the two living with him in Nigeria had tested positive for HIV while the one in the United States was HIV-negative due to distance and her ability to access pre-exposure prophylaxis, or PrEP.

February 5, 2021
Devex

Despite the incredible efficacy of oral pre-exposure prophylaxis (PrEP) and 78 countries currently offering PrEP in some form, its effectiveness at reducing HIV incidence in the real world has been dependent on far-reaching factors that go beyond how well PrEP is able to prevent HIV acquisition at a cellular level: political leadership, quality health services and funding.

February 1, 2021
aidsmap
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